|
Phosphoenolpyruvate carboxykinase deficiency
|
0.300 |
GermlineCausalMutation
|
disease |
ORPHANET |
Mitochondrial phosphoenolpyruvate carboxykinase deficiency.
|
2044592 |
1991 |
|
Phosphoenolpyruvate Carboxykinase Deficiency, Mitochondrial
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Steatohepatitis
|
0.120 |
AlteredExpression
|
disease |
BEFREE |
RESULTS; Expression of PEPCK was higher in steatohepatitis compared with steatosis alone and normal liver, and it was correlated with the homeostasis model assessment of insulin resistance (HOMA-IR) index.
|
18316359 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Since these are the major regulatory hormones controlling glucose homeostasis, and because increased hepatic glucose production is one of the characteristics of non-insulin dependent diabetes mellitus (NIDDM), investigators have speculated that the regulation of PEPCK gene expression may be defective in patients with NIDDM.
|
8547315 |
1995 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
For example, the expression of two hepatic genes, glucose-6-phosphatase and PEPCK, is normally inhibited by insulin, but in type 2 diabetes, their expression is insensitive to insulin.
|
11334436 |
2001 |
|
Diabetes
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
These results provide evidence for the interaction of insulin and glucocorticoid regulatory elements in the control of PEPCK gene transcription and suggest an important role of glucocorticoids as a gluconeogenic activator during diabetes.
|
7685354 |
1993 |
|
Diabetes
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The expression of the PEPCK gene in rat and human small intestine and the effect of streptozotocin-induced diabetes and fasting have been studied using reverse transcriptase-polymerase chain reaction, Northern blot analysis, and determination of enzyme activity.
|
10909974 |
2000 |
|
Diabetes Mellitus
|
0.050 |
AlteredExpression
|
group |
BEFREE |
These results provide evidence for the interaction of insulin and glucocorticoid regulatory elements in the control of PEPCK gene transcription and suggest an important role of glucocorticoids as a gluconeogenic activator during diabetes.
|
7685354 |
1993 |
|
Diabetes Mellitus
|
0.050 |
AlteredExpression
|
group |
BEFREE |
The expression of the PEPCK gene in rat and human small intestine and the effect of streptozotocin-induced diabetes and fasting have been studied using reverse transcriptase-polymerase chain reaction, Northern blot analysis, and determination of enzyme activity.
|
10909974 |
2000 |
|
Liver carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Here, we report that the expressions of both PCK1 and PCK2 genes are downregulated in primary hepatocellular carcinoma (HCC) and low PCK expression was associated with poor prognosis in patients with HCC.
|
29335519 |
2018 |
|
Liver carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
SR9009 treatment significantly decreased the mRNA level of Pck1 in mouse hepatoma Hepa-1c1c7 cells, whereas other major enzymes involved in gluconeogenesis (pyruvate carboxylase, glucose-6-phosphatase, fructose bisphosphatase and Pck2) and in glycolysis (phosphofructokinase and hexokinase-1) were unaffected.
|
30639375 |
2019 |
|
Liver neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
SR9009 treatment significantly decreased the mRNA level of Pck1 in mouse hepatoma Hepa-1c1c7 cells, whereas other major enzymes involved in gluconeogenesis (pyruvate carboxylase, glucose-6-phosphatase, fructose bisphosphatase and Pck2) and in glycolysis (phosphofructokinase and hexokinase-1) were unaffected.
|
30639375 |
2019 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Elevated PCK2 expression is observed in several human tumor types and enriched in tumor tissue from non-small-cell lung cancer (NSCLC) patients.
|
26474064 |
2015 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Information from prostate cancer patient databases revealed that higher PCK2 levels correlated with more aggressive tumors and lower survival rates.
|
29137367 |
2017 |
|
Hyperglycemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In addition, overexpression of Par14 in the insulin-resistant ob/ob mouse liver by adenoviral transfer significantly improved hyperglycemia with normalization of hepatic PEPCK and G6Pase mRNA levels, and gene suppression of Par14 using shRNA adenovirus significantly exacerbated the glucose intolerance in Pin1 KO mice.
|
23720771 |
2013 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
In pathological terms, PCK2 overexpression slowed TRC growth in vitro and impeded tumorigenesis in vivo.
|
28166201 |
2017 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Forced expression of either PCK1 or PCK2 in liver cancer cell lines results in severe apoptosis under the condition of glucose deprivation and suppressed liver tumorigenesis in mice.
|
29335519 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Elevated PCK2 expression is observed in several human tumor types and enriched in tumor tissue from non-small-cell lung cancer (NSCLC) patients.
|
26474064 |
2015 |
|
Hepatitis C
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In HepG2 cells expressing HCV core protein, the level of ROS increased, the value of NAD(+)/NADH decreased, the activity and expression levels of mRNA and protein of SIRT1 and AMPK decreased, glucose uptake and its regulator gene GLUT2 mRNA levels decreased, glucose production and its regulator genes PEPCK and G6Pase mRNA levels increased, intracellular TG and cholesterol contents and their regulator gene (SREBP-1c, FAS, ACC, HMGR, and HMGS) mRNA levels increased, the glycolytic gene GK and fatty acid oxidation genes PPARα and CPT1A mRNA levels decreased.
|
23510538 |
2013 |
|
melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma.
|
28166201 |
2017 |
|
Malnutrition
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A significant increase (P<0.05) in hepatic phosphoenolpyruvate carboxykinase (PEPCK) gene expression was found in male lambs of both undernourished groups, accompanied by increased (P<0.01) protein levels, while no differences were detected for glucose-6-phosphatase (G6Pase) mRNA abundance and protein levels.
|
28076749 |
2017 |
|
Adult Liver Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Forced expression of either PCK1 or PCK2 in liver cancer cell lines results in severe apoptosis under the condition of glucose deprivation and suppressed liver tumorigenesis in mice.
|
29335519 |
2018 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Forced expression of either PCK1 or PCK2 in liver cancer cell lines results in severe apoptosis under the condition of glucose deprivation and suppressed liver tumorigenesis in mice.
|
29335519 |
2018 |
|
Malignant neoplasm of liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Forced expression of either PCK1 or PCK2 in liver cancer cell lines results in severe apoptosis under the condition of glucose deprivation and suppressed liver tumorigenesis in mice.
|
29335519 |
2018 |
|
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Information from prostate cancer patient databases revealed that higher PCK2 levels correlated with more aggressive tumors and lower survival rates.
|
29137367 |
2017 |